Biochemical and Clinical Aspects of Ketone Body Metabolism
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چکیده
منابع مشابه
Biochemical and Clinical Aspects of Alcohol Metabolism
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Ketone bodies are metabolized through evolutionarily conserved pathways that support bioenergetic homeostasis, particularly in brain, heart, and skeletal muscle when carbohydrates are in short supply. The metabolism of ketone bodies interfaces with the tricarboxylic acid cycle, β-oxidation of fatty acids, de novo lipogenesis, sterol biosynthesis, glucose metabolism, the mitochondrial electron t...
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Garber, A. J., Menzel, P. H., Boden, G. & Owen, 0. E. (1974) J. Clin. Invest. 54,981-989 Long, C . L., Spencer, J. L., Kinney, J. M. & Geiger, J. W. (1971) J. Awl. Physiol. 31.102-109 Owen, 0. E., Reichard, G. A., Jr., Boden, G., Patel, M. S. & Trapp, V. E. (1978) in Advances in Modern Nutrition: Diabetes, Obesity and Vascular Disease (Katzen, H. M . & Mahler, R. J., eds.), vol. 2, pp. 517-550,...
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There is now no doubt that ketone bodies (acetoacetate and D-3-hydroxybutyrate) are important oxidizable substrates for peripheral tissues, especially the brain. Although oxidation is the major fate of ketone bodies, more recent evidence suggests that ketone bodies can act as lipogenic substrates in certain tissues, notably the developing brain and the lactating mammary gland. Apart from their ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1979
ISSN: 0014-5793
DOI: 10.1016/0014-5793(79)80995-3